Get a "Fishing Hot Spots" map of the lake, and you'll be fine. Just remember to subtract 5' from the depths indicated since the lake will be at winter pool. Some good free maps here to give you an idea of what the river does: http://kentuckylake.org/links/rivercharts.htm

You can run from Barkley to Kentucky pretty easily. I usually camp in the LBL so I can launch on either lake.